Annemieke Kavelaars Selected Research

G-protein-coupled receptor kinase 6

5/2012	G protein-coupled receptor kinase 6 acts as a critical regulator of cytokine-induced hyperalgesia by promoting phosphatidylinositol 3-kinase and inhibiting p38 signaling.
1/2009	G protein-coupled receptor kinase 6 controls post-inflammatory visceral hyperalgesia.
6/2007	G protein-coupled receptor kinase 6 controls chronicity and severity of dextran sodium sulphate-induced colitis in mice.
12/2003	Increased acute inflammation, leukotriene B4-induced chemotaxis, and signaling in mice deficient for G protein-coupled receptor kinase 6.

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Annemieke Kavelaars Research Topics

Disease

29	Hyperalgesia 01/2022 - 03/2007
27	Inflammation (Inflammations) 01/2020 - 04/2003
25	Neoplasms (Cancer) 01/2022 - 09/2002
23	Pain (Aches) 01/2022 - 03/2007
19	Peripheral Nervous System Diseases (PNS Diseases) 01/2022 - 01/2014
16	Neuralgia (Stump Neuralgia) 01/2022 - 06/2012
13	Brain Injuries (Brain Injury) 03/2014 - 10/2005
13	Hypoxia (Hypoxemia) 07/2010 - 04/2004
12	Chronic Pain 01/2022 - 08/2011
12	Ischemia 04/2009 - 04/2004
10	Cognitive Dysfunction 01/2022 - 01/2016
9	Mitochondrial Diseases (Mitochondrial Disease) 01/2022 - 11/2015
9	Fatigue 07/2018 - 02/2007
8	Post-Traumatic Stress Disorders (Post Traumatic Stress Disorder) 01/2015 - 01/2011
7	Hypersensitivity (Allergy) 01/2022 - 12/2006
7	Chemotherapy-Related Cognitive Impairment 01/2022 - 01/2016
6	Brain Hypoxia-Ischemia (Hypoxia Ischemia, Brain) 05/2010 - 04/2004
5	Neuroinflammatory Diseases 10/2020 - 10/2005
5	Wounds and Injuries (Trauma) 05/2013 - 09/2008
4	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 01/2013 - 04/2003
4	Lung Diseases (Lung Disease) 11/2008 - 12/2006
3	Multiple Sclerosis 01/2020 - 04/2005
3	Hypesthesia (Numbness) 01/2019 - 10/2016
3	Colitis 01/2009 - 06/2007
2	Bronchopulmonary Dysplasia 03/2015 - 07/2013
2	Gliosis 11/2014 - 01/2011
2	Necrosis 05/2014 - 01/2005
2	Stroke (Strokes) 05/2013 - 04/2012
2	Ventilator-Induced Lung Injury 01/2013 - 12/2010
2	Atherosclerosis 01/2013 - 02/2011
2	Visceral Pain 01/2009 - 10/2007
2	Birth Weight (Birth Weights) 04/2008 - 12/2006

Drug/Important Bio-Agent (IBA)

20	Cisplatin (Platino)FDA LinkGeneric 01/2022 - 01/2014
20	CytokinesIBA 01/2020 - 03/2005
13	Proteins (Proteins, Gene)FDA Link 10/2020 - 04/2003
11	Interleukin-10 (Interleukin 10)IBA 01/2022 - 01/2008
9	Phosphotransferases (Kinase)IBA 10/2021 - 08/2011
9	GlucocorticoidsIBA 03/2015 - 01/2005
9	Hydrocortisone (Cortisol)FDA LinkGeneric 05/2013 - 12/2006
8	Paclitaxel (Taxol)FDA LinkGeneric 01/2021 - 01/2014
8	G-Protein-Coupled Receptor Kinase 2IBA 01/2018 - 04/2004
8	ChemokinesIBA 01/2014 - 05/2004
8	Dexamethasone (Maxidex)FDA LinkGeneric 07/2013 - 12/2006
7	Pharmaceutical PreparationsIBA 01/2022 - 01/2014
6	InterleukinsIBA 12/2018 - 02/2008
6	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 05/2012 - 08/2004
6	NF-kappa B (NF-kB)IBA 05/2010 - 01/2005
5	Messenger RNA (mRNA)IBA 01/2016 - 01/2005
5	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2009 - 04/2003
4	Histone Deacetylase 6IBA 01/2022 - 10/2018
4	erythromycin propionate-N-acetylcysteinateIBA 05/2018 - 09/2010
4	Biomarkers (Surrogate Marker)IBA 01/2018 - 01/2011
4	Biological ProductsIBA 01/2015 - 02/2012
4	CarrageenanIBA 05/2014 - 02/2010
4	G-Protein-Coupled Receptor KinasesIBA 05/2014 - 08/2011
4	Glucocorticoid Receptors (Glucocorticoid Receptor)IBA 11/2012 - 11/2009
4	G-protein-coupled receptor kinase 6IBA 05/2012 - 12/2003
3	PlatinumIBA 01/2022 - 11/2015
3	Metformin (Glucophage)FDA LinkGeneric 08/2019 - 01/2014
3	3- (5- tert- butylisoxazol- 3- yl)- 2- ((3- chlorophenyl)hydrazono)- 3- oxopropionitrileIBA 05/2018 - 03/2016
3	EnzymesIBA 11/2017 - 01/2005
3	pifithrinIBA 01/2017 - 11/2015
3	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 03/2014 - 07/2010
3	Nitric Oxide (Nitrogen Monoxide)FDA Link 04/2009 - 10/2005
3	Drinking WaterIBA 01/2009 - 06/2007
3	Dextrans (Dextran)FDA Link 01/2009 - 06/2007
3	Neurotransmitter Agents (Neurotransmitter)IBA 03/2008 - 04/2005
3	2-iminobiotinIBA 02/2007 - 01/2005
2	Interleukin-10 ReceptorsIBA 01/2022 - 10/2020
2	Liposomes (Liposome)IBA 01/2022 - 01/2016
2	Clodronic Acid (Clodronate)IBA 01/2022 - 01/2016
2	ricolinostatIBA 12/2019 - 01/2017
2	Indoleamine-Pyrrole 2,3,-Dioxygenase (Indoleamine 2,3 Dioxygenase)IBA 01/2019 - 05/2015
2	KynurenineIBA 12/2018 - 11/2017
2	Tryptophan (L-Tryptophan)FDA Link 12/2018 - 05/2015
2	Interleukin-6 (Interleukin 6)IBA 07/2018 - 04/2002
2	Dinoprostone (PGE2)FDA Link 01/2018 - 09/2010
2	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 11/2017 - 10/2012
2	Interleukin-1 (Interleukin 1)IBA 11/2017 - 09/2010
2	Neuroprotective AgentsIBA 01/2017 - 01/2005
2	LipopolysaccharidesIBA 01/2016 - 05/2014
2	Tamoxifen FDA LinkGeneric 07/2015 - 07/2011
2	Interleukin 1 Receptor Antagonist Protein (Anakinra)FDA Link 05/2015 - 09/2010
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2013 - 12/2010
2	Protein Kinases (Protein Kinase)IBA 07/2011 - 09/2010
2	ManganeseIBA 01/2011 - 04/2009
2	Interleukin-1beta (Interleukin 1 beta)IBA 09/2010 - 02/2008
2	salicylhydroxamic acid (SHAM)IBA 07/2010 - 04/2009
2	Erythropoietin FDA Link 02/2009 - 11/2008
2	Capsaicin (Zostrix)FDA Link 01/2009 - 10/2007
2	SodiumIBA 01/2009 - 06/2007

Therapy/Procedure

29	Drug Therapy (Chemotherapy) 01/2022 - 01/2014
16	Therapeutics 01/2019 - 02/2009
6	Intranasal Administration 01/2022 - 05/2013
2	Aftercare (After-Treatment) 01/2022 - 10/2018
2	Remission Induction 07/2018 - 01/2018
2	Oral Administration 01/2018 - 11/2002
2	Radiotherapy 01/2017 - 01/2016
2	Spinal Injections 10/2016 - 05/2014
2	Drug Tapering 11/2015 - 01/2015